Jesmine Ho became a world bowling champion when she defeated Denmark's Iben Tchu for the Ladies' Master title at the inaugural World Bowling Masters Championship at Abu Dhabi in April 2001. This tournament pitted the top eight men and eight women from each of three continents - America, Asia and Europe. She was only the second Singaporean to have won a world bowling title. The year before, she was ranked the top amateur bowler in a prestigious US bowling magazine – the Bowlers International Journal.

Having first picked up bowling at the age of 23, Jesmine did well at tournaments and was urged to try out for the national team. She made the grade and represented Singapore at several competitions. However, after the Asian FIQ Championships in 1992, she decided to retire.

Fortunately for Singapore , Ho made a comeback in 1995 and made an immediate impact. She and Katherine Lee won the doubles silver medal at the World FIQ Championships in Reno, making them the first Singaporean women medallists, then.

From then on, there was no stopping her. She not only won the Asian Games silver medal in 1998, but also the Champion of Champions title, Singapore Masters Cup and the Singapore Open title. In 1999, her achievements included the ATBC Championship title, SEA Games silver and bronze medals and the Cathay Super Bowl Classic title. She also made a clean sweep at the Malaysian Open, Malaysia Masters Cup, Champion of Champions and the First Tournament of Champions, the year after.

She peaked at the inaugural World Masters Bowling Championship in 2001 winning the Ladies' Masters title and consequently, a place in sports history at the SSC Hall of Fame.